You've probably never heard of the Churamane, have you? They were a particularly lazy and not terribly bright species that lived a long time ago and vanished without a trace. This story follows them from the time they get invited aboard Noah's Ark, all the way up to the moment they finally arrive at the boat... only to realize that they're late and have been locked out! They come to realize that they've literally missed the boat on survival, and have doomed their entire species to extinction.
SDCC: Marvel: Spider-Man and His Amazing Friends Panel