According to The Hollywood Reporter, the Warner Bros. sequel is set to take advantage of the Easter holiday and dominate the box office over the March 25-27 weekend. The studio's internal reports suggest a more modest opening, targeting a three-day take of $110 million.
Either number would place the sequel in the top 10 openings of all time for a superhero film.
A report by BoxOffice.com in early February had the film poised for a $154 million opening weekend on the way to a final domestic haul of $380 million.
"Man of Steel" opened in 2013 with $116.6 million (not counting the $12 million earned in special Walmart screenings), on its way to a $291 million domestic haul.
Directed by Zack Snyder, "Batman v Superman: Dawn of Justice" stars Ben Affleck, Henry Cavill and Gal Gadot. The film opens March 25.