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Director Bryan Singer's film scored the best worldwide debut of any installment of the Fox franchise.
The latest X-Men film brings in $261.8 million globally in its opening weekend, with an estimated $90.7 million in North America.
The king of the monsters stomps the competition and brings Warner Bros. its largest May opening ever.
The Sony and Marvel film holds tight to the No. 1 spot internationally as it webs up a total of $550 million worldwide to date.
The new comedy starring Seth Rogen and Zac Efron looks to top the North American weekend box office, pushing "Amazing" to No. 2.
After teasing films ranging from "Neighbors" to "Dumb and Dumber To," Angelina Jolie appeared to promote Universal's "Unbroken."